Antifungal Activities of Peptides Derived from Domain 5 of High-Molecular-Weight Kininogen

Table 1

D5-derived and control peptides investigated.

Peptide	Sequence	Mw	pI^1	Net charge	Mean hydrophobicity^2
KHN20	KHNLGHGHKHERDQGHGHQR	2365.5	9.99	+2	−4.91
GHG20	GHGLGHGHEQQHGLGHGHKF	2127.2	7.21	0	−2.01
GHG21	GHGHKFKLDDDLEHQGGHVLD	2354.5	5.63	−3	−2.32
GGH20	GGHVLDHGHKHKHGHGHGKH	2169.3	9.70	+2	−3.44
HKH20	HKHGHGHGKHKNKGKKNGKH	2151.5	10.78	+7	−5.91
GKH17	GKHKNKGKKNGKHNGWK	1946	10.78	+7	−5.77
GKH17WWW	GKHKNKGKKNGKHNGWKWWW	2505	10.78	+7	−3.45
GKH17WWWWW	GKHKNKGKKNGKHNGWKWWWWW	2287	10.78	+7	−2.25
LL-37	LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES	4492	10.61	+6	−1.84
Histatin-5	DSHAKRHHGYKRKFHEKHHSHRGY	3036	10.28	+5	−4.67

Mw: molecular weight. ¹pI: theoretical isoelectric point calculated by using the Protparam tool available at http://us.expasy.org/tools/protparam.html. ²Mean hydrophobicity calculated using HydroMCalc (combined consensus hydrophobicity scale) available at http://www.bbcm.univ.trieste.it/~tossi/HydroCalc/HydroMCalc.html.