Amyloid Beta Peptide Slows Down Sensory-Induced Hippocampal Oscillations

<table>Amyloid beta slows, in a dose-dependent manner, the oscillatory activity induced by sensory stimulation. Change in power induced by sensory stimulation in control rats (black circles; <svg height="11.175" id="M21" style="vertical-align:-0.20474pt" version="1.1" viewbox="0 0 36.237499 11.175" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.862)"><path d="M495 86q-46 -47 -87 -72.5t-63 -25.5q-43 0 -16 107l49 210q7 34 8 50.5t-3 21t-13 4.5q-35 0 -109.5 -72.5t-115.5 -140.5q-21 -75 -38 -159q-50 -10 -76 -21l-6 8l84 340q8 35 -4 35q-17 0 -67 -46l-15 26q44 44 85.5 70.5t64.5 26.5q35 0 10 -103l-24 -98h2
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</svg>) compared to that in amyloid beta-injected rats (gray circles; <svg height="11.225" id="M22" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>). Animals were injected with two doses of amyloid beta. With 5 pmoles (a), the increase in power, upon sensory stimulation, shifts towards slow frequencies. Injection of 50 pmoles of amyloid beta (b) also shifts the increase in power, upon sensory stimulation, towards slow frequencies, and it also significantly reduces the increase in theta rhythm. *Indicates a significant difference compared to control rats (<svg height="11.375" id="M23" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x35"></use></g>
</svg>; Mann-Whitney <svg height="11.4625" id="M24" style="vertical-align:-0.23206pt" version="1.1" viewbox="0 0 13.1 11.4625" width="13.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><path d="M751 650l-6 -28q-53 -1 -69 -12.5t-24 -38.5q-23 -85 -43 -192l-13 -69q-34 -181 -130 -262q-79 -65 -185 -65t-171 57q-87 77 -54 258l42 232q12 58 0.5 73t-75.5 19l8 28h263l-6 -28q-63 -5 -78 -18t-26 -74l-41 -226q-25 -135 22 -201t139 -66q99 0 161.5 68t91.5 217
l11 57q28 149 28 193q0 28 -19 38t-79 12l6 28h247z" id="x1D448"></path></g>
</svg> test).</table>

International Journal of Peptides

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Figure 3

Figure 3: Amyloid Beta Peptide Slows Down Sensory-Induced Hippocampal Oscillations 