Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi
Figure 2
ic2 peptide effect on γ-[35S]-GTP incorporated into Gi, a measure of G-protein activation. Control is the basal amount of γ-[35S]-GTP incorporated into Gi in CHO cells expressing the human 5HT1aR, set as 100%. The -axis is the percent of specifically bound (total minus nonspecific) γ-[35S]-GTP. All other treatments are percents of the control value. All peptides are 30 uM concentration and 5HT 10−7 M concentration. Error is expressed as SEM.
