Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi

Figure 4

P12 and P13-stimulated incorporation of γ-[³⁵S]-GTP control is the basal amount of γ-[³⁵S]-GTP incorporated into Gi in CHO cells expressing the human 5HT1aR set as 100%. The 𝑌 axis is the percent of specifically bound γ-[³⁵S]-GTP. All other treatments are percents of the control value. Peptide concentrations are 30 uM. *𝑃<0.01 P12 versus control; ^€𝑃<0.01 5HT versus 5HT/P12. *P13 versus control 𝑃<0.01; ^€5HT versus 5HT/P13 𝑃<0.01.