Research Article

Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi

Table 1

ic2 and ic3 peptide mimics. The primary amino acid sequences for the H5HT1aR ic2 loop peptide mimics P11 and P’s 21–27, and for ic3 (P1, P12, and P13). The receptor’s amino terminal is to the left. Sequences for H5HT1aR from Kobilka et al., 1987 [56]. P11 is from a previous study by Thiagaraj et al., 2007 [53], and P1 from Hayataka et al., 1988 [49] (both included for comparative purposes).

P11IALDRYWAITD
P21 LDRYWAITDP
P22  RYWAITDPID
P23   WAITDPIDYV
P24    ITDPIDYVNK
P25     DPIDYVNKRT
P26       IDYVNKRTPR
P27       YVNKRTPRPR
P1IFRAARFRIRKTVKK
P12         KTVKKVEKTG
P13          VKKVEKTGAD