Proline Rich Motifs as Drug Targets in Immune Mediated Disorders

Table 1

The dihedral angles of the proline-rich motifs in selected immune-response-related proteins.

Class			Motif	Critical proline
Cell surface proteins	CD152			Phi	Psi
	Mouse	1DQT	MYPPPY	−84	167
	Human	1I8L	MYPPPY	−76	164.6
	CD28
	Mouse	Model	MYPPPY	−53.4	166.5
	Human		MYPPPY	−55.4	165.3
	ICOS
	Mouse	Model	FDPPP	−53.4	167.4
	Human		FDPPP	−83.9	124.2
Cytoskeletal proteins	WIP	2IFS	LPPP	−65.9	157.3
		1MKE	LPPP	−75	158.1
Transcriptional factors	GILZ
	Human	Molecular Model	PEAP	−67.5	142.5
	Mouse		PEAP	−72.5	162.3
	SMRT
	Human	2ODD	PPP	−70	158.4