A Systematic Review to Investigate Whether Angiotensin-(1-7) Is a Promising Therapeutic Target in Human Heart Failure

Table 1

Studies on human heart failure patients.

Study	Full publication or abstract	N	Endpoint	Key findings
Davie and McMurray [31]	Full	8	Blood pressure, forearm blood flow (FBF)	Ang-(1-7) has no significant effect on the endpoints.
Zisman et al. [12]	Full	22	Ang-(1-7) forming activity	Ang-(1-7) forming activity is increased in failing heart.
Campbell et al. [13]	Full	9	Ang-(1-7) levels in arterial and coronary sinus blood	39- and 22-fold increase of Ang-(1-7) levels in the coronary sinus and arterial blood, respectively (patients were receiving ACE inhibitor therapy).; A parallel increase in Ang-(1-7) and Ang I levels was observed in HF patients on ACE inhibitors.; A 7.5- and 2.25-fold increase in the Ang-(1-7)/Ang II ratio was associated with ACE inhibition in the coronary sinus and arterial blood, respectively.
Batlle Perales et al. [32]	Abstract	33 (end-stage HF); 11 (control)		Increased Mas receptor expression within myocardiums in the remodelling stage (as suggested by MMP3 and collagen I). Ang-(1-7) is therefore suggested to have a role in the remodelling process.