Significant Increase in Salivary Substance P Level after a Single Oral Dose of Cevimeline in Humans

Table 1

Total amounts of substance-P- (SP-), calcitonin-gene-related-peptide- (CGRP-), and vasoactive-intestinal-polypeptide-(VIP-) like immunoreactive substance in saliva released after administration of　cevimeline or placebo to 7 healthy volunteers.

Drugs	AUC0--240 in saliva (pg min/mL)
	SP	CGRP	VIP
Cevimeline	2420.9 ± 744.6**	3014.4 ± 2009.3	389.8 ± 120.4
Placebo	1185.8 ± 398.6	1644.1 ± 1094.7	288.3 ± 125.7

Data are expressed as mean ± SD, **𝑃<0.01 versus placebo.