Antigenic Peptides Capable of Inducing Specific Antibodies for Detection of the Major Alterations Found in Type 2B Von Willebrand Disease

Table 1

Proposed synthetic peptides for detection of the major qualitative alterations found in VWD type 2B.

Major qualitative alterations found in VWD type 2B	Designed 8 mer peptides for synthesis	Theoretical [M + H]^+	Observed [M + H]^+	Respective peptide from M. musculus VWF
R1306W	MEWLRISY	1097.54	1113.56*	MERLHIS
R1308C	MERLCISY	1014.47	1014.50
	Respective peptide found in H. sapiens VWF: MERLRISY	1067.56	1082.57*
V1316M	SQKWVRMA	1005.52	1020.54*	SQKRIRVA
	Respective peptide found in H. sapiens VWF: SQKWVRVA	973.55	972.57 [−1H^+]
R1341Q	RPSELQRY	1048.55	1048.57	RPSELRR
	Respective peptide found in H. sapiens VWF: RPSELRRY	1076.59	1076.62

∗Peptide mass containing an oxidized methionine.