Table of Contents
International Journal of Peptides
Volume 2013, Article ID 907850, 5 pages
http://dx.doi.org/10.1155/2013/907850
Research Article

Interaction between Pirenzepine and Ninjinto, a Traditional Japanese Herbal Medicine, on the Plasma Gut-Regulated Peptide Levels in Humans

Department of Pharmacy, Oita University Hospital, 1-1 Idaigaoka, Hasama-Machi, Oita 879-5593, Japan

Received 26 November 2012; Revised 11 February 2013; Accepted 5 March 2013

Academic Editor: Eva Ekblad

Copyright © 2013 Yuhki Sato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Sekiya and Y. Morimoto, “Effect of several Kampo medicines on postoperative ileus model,” The Japan Jounal of Oriental Medicine, vol. 54, pp. 785–790, 2003. View at Google Scholar
  2. T. Naito, H. Itoh, T. Nagano, and M. Takeyama, “Effects of Ninjin-to on levels of brain-gut peptides (Motilin, vasoactive intestinal peptide, gastrin, and somatostatin) in human plasma,” Biological and Pharmaceutical Bulletin, vol. 24, no. 2, pp. 194–196, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Sato, F. Katagiri, S. Inoue, H. Itoh, and M. Takeyama, “Dai-kenchu-to raises levels of calcitonin gene-related peptide and substance P in human plasma,” Biological and Pharmaceutical Bulletin, vol. 27, no. 11, pp. 1875–1877, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. I. L. Gibbins, J. B. Furness, and M. Costa, “Pathway-specific patterns of the co-existence of substance P, calcitonin gene-related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea-pig,” Cell and Tissue Research, vol. 248, no. 2, pp. 417–437, 1987. View at Google Scholar · View at Scopus
  5. H. Kimura, S. Ito, T. Ohta, T. Asano, and Y. Nakazato, “Vasoactive intestinal peptide released by acetylcholine in the dog ileum,” Journal of the Autonomic Nervous System, vol. 48, no. 2, pp. 167–174, 1994. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Trasforini, A. Margutti, L. Vergnani et al., “Evidence that enhancement of cholinergic tone increases basal plasma levels of calcitonin gene-related peptide in normal man,” Journal of Clinical Endocrinology and Metabolism, vol. 78, no. 3, pp. 763–766, 1994. View at Publisher · View at Google Scholar · View at Scopus
  7. P. T. Schmidt and J. J. Holst, “Use of antagonists to define tachykininergic control of intestinal motility in pigs,” Peptides, vol. 18, no. 3, pp. 373–379, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. J. E. T. Fox, E. E. Daniel, J. Jury, N. S. Track, and S. Chiu, “Cholinergic control mechanisms for immunoreactive motilin release and motility in the canine duodenum,” Canadian Journal of Physiology and Pharmacology, vol. 61, no. 9, pp. 1042–1049, 1983. View at Google Scholar · View at Scopus
  9. D. K. Nelson, O. Pieramico, G. Dahmen, J. E. Dominguez-Munoz, P. Malfertheiner, and G. Adler, “M1-muscarinic mechanisms regulate interdigestive cycling of motor and secretory activity in human upper gut,” Digestive Diseases and Sciences, vol. 41, no. 10, pp. 2006–2015, 1996. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Poitras, A. Dumont, J. C. Cuber, and L. Trudel, “Cholinergic regulation of motilin release from isolated canine intestinal cells,” Peptides, vol. 14, no. 2, pp. 207–213, 1993. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Yamada, A. Mizumoto, M. Satoh, N. Haga, and Z. Itoh, “Muscarinic control of phase III contractions and motilin release in dogs,” Peptides, vol. 18, no. 5, pp. 673–680, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Hammer, C. P. Berrie, and N. J. M. Birdsall, “Pirenzepine distinguishes between different subclasses of muscarinic receptors,” Nature, vol. 283, no. 5742, pp. 90–92, 1980. View at Google Scholar · View at Scopus
  13. Y. Matsuo and A. Seki, “Actions of pirenzepine dihydrochloride (LS 519 Cl) on gastric juice secretion, gastric motility and experimental gastric ulcer,” Arzneimittelforschuang, vol. 29, no. 7, pp. 1028–1035, 1979. View at Google Scholar · View at Scopus
  14. R. Sue, M. L. Toomey, A. Todisco, A. H. Soll, and T. Yamada, “Pirenzepine-sensitive muscarinic receptors regulate gastric somatostatin and gastrin,” The American Journal of Physiology, vol. 248, no. 2, pp. G184–G187, 1985. View at Google Scholar · View at Scopus
  15. T. Nagano, K. Ikawa, and M. Takeyama, “Enzyme immunoassay of calcitonin gene-related peptide-like immunoreactive substance in human plasma and saliva,” The Japanese Journal of Hospital Pharmacy, vol. 24, pp. 363–369, 1998. View at Google Scholar
  16. M. Takeyama, K. Mori, F. Takayama, K. Kondo, K. Kitagawa, and N. Fujii, “Enzyme immunoassay of a substance P-like immunoreactive substance in human plasma and saliva,” Chemical and Pharmaceutical Bulletin, vol. 38, no. 12, pp. 3494–3496, 1990. View at Google Scholar · View at Scopus
  17. M. Takeyama, K. Wakayama, F. Takayama, K. Kondo, N. Fujii, and H. Yajima, “Micro-enzyme immunoassay of vasoactive intestinal polypeptide (VIP)-like immunoreactive substance in bovine milk,” Chemical and Pharmaceutical Bulletin, vol. 38, no. 4, pp. 960–962, 1990. View at Google Scholar · View at Scopus
  18. T. Naito, H. Itoh, F. Yasunaga, and M. Takeyama, “Hange-shashin-to raises levels of somatostatin, motilin, and gastrin in the plasma of healthy subjects,” Biological and Pharmaceutical Bulletin, vol. 25, no. 3, pp. 327–331, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. F. Katagiri, Y. Sato, H. Itoh, and M. Takeyama, “Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma,” Journal of Pharmacy and Pharmacology, vol. 56, no. 4, pp. 557–561, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Takeyama, K. Kondo, Y. Hayashi, and H. Yajima, “Enzyme immunoassay of gastrin releasing peptide (GRP)-like immunoreactivity in milk,” International Journal of Peptide and Protein Research, vol. 34, no. 1, pp. 70–74, 1989. View at Google Scholar · View at Scopus
  21. T. Kitagawa, T. Shimozono, T. Aikawa, T. Yoshida, and H. Nishimura, “Preparation and characterization of hetero-bifunctional cross-linking reagents for protein modifications,” Chemical Pharmceutical Bulluten, vol. 29, pp. 1130–1135, 1981. View at Google Scholar
  22. Y. Kinoshita, T. Inui, and T. Chiba, “Calcitonin gene-related peptide: a neurotransmitter involved in capsaicin- sensitive afferent nerve-mediated gastric mucosal protection,” Journal of Clinical Gastroenterology, vol. 17, supplement 1, pp. S27–S32, 1993. View at Google Scholar · View at Scopus
  23. P. Holzer, E. H. Livingston, A. Saria, and P. H. Guth, “Sensory neurons mediate protective vasodilatation in rat gastric mucosa,” American Journal of Physiology, vol. 260, no. 3, pp. G363–G370, 1991. View at Google Scholar · View at Scopus
  24. P. Holzer, “Neural emergency system in the stomach,” Gastroenterology, vol. 114, no. 4, pp. 823–839, 1998. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Fontaine, A. Klarsfeld, T. Hokfeld, and J. P. Changeux, “Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes,” Neuroscience Letters, vol. 71, no. 1, pp. 59–65, 1986. View at Google Scholar · View at Scopus
  26. P. M. Hellstrom, O. Soder, and E. Theodorsson, “Occurrence, release, and effects of multiple tachykinins in cat colonic tissues and nerves,” Gastroenterology, vol. 100, no. 2, pp. 431–440, 1991. View at Google Scholar · View at Scopus
  27. P. T. Schmidt and J. J. Holst, “Use of antagonists to define tachykininergic control of intestinal motility in pigs,” Peptides, vol. 18, no. 3, pp. 373–379, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. J. C. Brown, “Presence of a gastric motor-stimulating property in duodenal extracts,” Gastroenterology, vol. 52, no. 2, pp. 225–229, 1967. View at Google Scholar · View at Scopus
  29. N. Ling, R. Burgus, J. Rivier, W. Vale, and P. Brazeau, “The use of mass spectrometry in deducing the sequence of somatostatin—a hypothalamic polypeptide that inhibits the secretion of growth hormone,” Biochemical and Biophysical Research Communications, vol. 50, no. 1, pp. 127–133, 1973. View at Google Scholar · View at Scopus
  30. C. H. You, W. Y. Chey, and K. Y. Lee, “Studies on plasma motilin concentration and interdigestive motility of the duodenum in humans,” Gastroenterology, vol. 79, no. 1, pp. 62–66, 1980. View at Google Scholar · View at Scopus
  31. P. Thor, R. Król, S. J. Konturek, D. H. Coy, and A. V. Schally, “Effect of somatostatin on myoelectrical activity of small bowel,” The American Journal of Physiology, vol. 235, no. 3, pp. E249–E254, 1978. View at Google Scholar · View at Scopus