Interaction between Pirenzepine and Ninjinto, a Traditional Japanese Herbal Medicine, on the Plasma Gut-Regulated Peptide Levels in Humans
Total amount of substance-P-, CGRP-, and VIP-IS released in plasma after the administration of Ninjinto (6.0 g) to 5 healthy volunteers with or without pirenzepine (75 mg) treatment.
Plasma AUC (pg mL/min)
Ninjinto (6.0 g)
Ninjinto (6.0 g) + pirenzepine (75 mg)
Each value represents the mean ± s.d. . AUC , area under the plasma concentration-time curve from 0 to 240 min. * and ** significantly different compared with placebo. † significantly different compared with Ninjinto alone.