Table 2: Total amount of CGRP-, substance-P-, motilin-, somatostatin-, and VIP-IS released in plasma after the administration of pirenzepine (75 mg) to 5 healthy volunteers.

Plasma AUC (pg mL/min)
Pirenzepine (75 mg)Placebo

CGRP **
Substance P
Motilin
Somatostatin *
VIP

Each value represents the mean ± s.d. . AUC , area under the plasma concentration-time curve from 0 to 240 min. * and ** significantly different compared with placebo.