International Journal of Peptides / 2016 / Article / Tab 3

Research Article

Netrin-1 Peptide Is a Chemorepellent in Tetrahymena thermophila

Table 3

A comparison of polycationic peptides and proteins which are chemorepellents in Tetrahymena. Calcium is required for avoidance of all of the compounds listed except for netrin-1 peptide, suggesting a unique signaling mechanism for this peptide. Netrin-1 peptide also has one of the lowest EC100 values of the polycationic compounds studied to date, suggesting a high affinity for its putative receptor.

ChemorepellentCharge at pH 7.0EC100Calcium required for avoidance?Reference

Lysozyme+11100 μMYesKuruvilla et al., 1997 [9]; Kuruvilla and Hennessey, 1998 [14]
PACAP-38+110.1 μMYesMace et al., 2000 [12]
Nociceptin+4100 μMYesLampert et al., 2013 [13]
Netrin-1 peptide+61 μMNoCurrent study

Electrophysiological studies done. Results obtained using pharmacological inhibitors only.

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