Amyloid β Peptide-Induced Changes in Prefrontal Cortex Activity and Its Response to Hippocampal Input

Figure 1

Aβ inhibits PFC spontaneous population activity. At the top, representative traces of PFC spontaneous activity are shown recorded in basal conditions (black traces) and after 60 min of continuous application of Aβ (30 nM; gray traces). Their corresponding power spectra are shown at the bottom, and the integrated power for each condition (basal power set as 100%) is shown as an inset. Note that Aβ application significantly reduces the power of the PFC spontaneous population activity. Data are presented as mean ± SEM. versus control activity ( slices).