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International Journal of Plant Genomics
Volume 2008 (2008), Article ID 619832, 12 pages
http://dx.doi.org/10.1155/2008/619832
Resource Review

Blast2GO: A Comprehensive Suite for Functional Analysis in Plant Genomics

Bioinformatics Department, Centro de Investigación Príncipe Felipe, Valencia 4012, Spain

Received 5 October 2007; Accepted 26 November 2007

Academic Editor: Chunguang Du

Copyright © 2008 Ana Conesa and Stefan Götz. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Functional annotation of novel sequence data is a primary requirement for the utilization of functional genomics approaches in plant research. In this paper, we describe the Blast2GO suite as a comprehensive bioinformatics tool for functional annotation of sequences and data mining on the resulting annotations, primarily based on the gene ontology (GO) vocabulary. Blast2GO optimizes function transfer from homologous sequences through an elaborate algorithm that considers similarity, the extension of the homology, the database of choice, the GO hierarchy, and the quality of the original annotations. The tool includes numerous functions for the visualization, management, and statistical analysis of annotation results, including gene set enrichment analysis. The application supports InterPro, enzyme codes, KEGG pathways, GO direct acyclic graphs (DAGs), and GOSlim. Blast2GO is a suitable tool for plant genomics research because of its versatility, easy installation, and friendly use.