Table of Contents
International Journal of Photochemistry
Volume 2014 (2014), Article ID 176989, 4 pages
http://dx.doi.org/10.1155/2014/176989
Research Article

Photoinduced Aromatization of Asymmetrically Substituted 1,4-Dihydropyridine Derivative Drug Cilnidipine

Organic Chemistry Section, Department of Chemistry, Uttaranchal University, Dehradun 248001, India

Received 24 July 2014; Accepted 29 September 2014; Published 20 October 2014

Academic Editor: M. El-Khouly

Copyright © 2014 Waseem Ahmad. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antihypertensive drug Cilnidipine (1) is photolabile under UV-A light. Irradiation of a chloroform solution of Cilnidipine under aerobic and anaerobic conditions produces a common photoproduct which was isolated as 2-methoxyethyl-3-phenyl-2-propenyl pyridine dihydro-2,6-dimethyl-4-(3-nitrophenyl) pyridine-3,5-dicarboxylate (2). The formation of products was explained by photochemical aromatization of Cilnidipine.