Expression of Heat Shock and Other Stress Response Proteins in Ticks and Cultured Tick Cells in Response to Anaplasma spp. Infection and Heat Shock

Table 1

HSP differential expression between A. phagocytophilum-infected and control-uninfected I. scapularis ISE6 tick cells.

Protein description	Fold change	UNIPROT accession number	FDR
HSP70-2	+1.42	B4YTT9	0.000
HSP70-1	+1.30	B4YTT8	0.002
HSP70	+1.20	B7PEN4	0.011
HSP, putative	−1.45	B7P1Z8	0.016
HSP20, putative	−5.81	B7P7F7	0.004

^a+ and − indicate protein overexpression and underexpression in A. phagocytophilum-infected cells, respectively.
bFalse discovery rate (FDR) was used as a measure of statistical significance of peptide identification and was calculated using the refined method proposed by Navarro and Vazquez [32].