Research Article

Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease

Table 5

Component location and function associated with significantly up- or downregulated proteins identified in CKD patients.

LocationFunction
Gene ontology termCluster frequency -valueFDRProteins annotated to the GO TermGene ontology termCluster frequency valueFDRProteins annotated to the GO term

Extracellular region18 of 23 proteins, 78.3%7.36 −150.00%EGF, IGHG1, LRG, AMBP, AZGP1, KNG1, SERPING1, TF, LGALS3BP, FETUA, CP, HP, SERPINC1, IGHG2, ORM1, APOD, PTGDS, UMODBinding20 of 23 proteins, 87.0%0.000510.89%EGF, IGHG1, AMBP, CUBN, AZGP1, KNG1, SERPING1, TF, LGALS3BP, GAA, FETUA, CP, SERPINC1, HP, IGHG2, GLB1, ORM1, APOD, PTGDS, UMOD
Extracellular space11 of 23 proteins, 47.8%5.47 −110.00%EGF, LGALS3BP, CP, FETUA, SERPINC1, APOD, ORM1, PTGDS, UMOD, KNG1, SERPING1Protein binding15 of 23 proteins, 65.2%0.000660.80%TF, EGF, IGHG1, LGALS3BP, CP, FETUA, AMBP, HP, SERPINC1, APOD, ORM1, GLB1, CUBN, KNG1, SERPING1
Extracellular region part11 of 23 proteins, 47.8%1.13 −090.00%EGF, LGALS3BP, CP, FETUA, SERPINC1, APOD, ORM1, PTGDS, UMOD, KNG1, SERPING1Enzyme regulator activity6 of 23 proteins, 26.1%0.000240.00%EGF, SERPINC1, FETUA, KNG1, AMBP, SERPING1
Cytoplasmic vesicle6 of 23 proteins, 26.1%6.81 −050.20%TF, EGF, CUBN, UMOD, KNG1, SERPING1Endopeptidase inhibitor activity5 of 23 proteins, 21.7%3.78 −070.00%SERPINC1, FETUA, KNG1, AMBP, SERPING1
Vesicle6 of 23 proteins, 26.1%8.57 −050.18%TF, EGF, CUBN, UMOD, KNG1, SERPING1Endopeptidase regulator activity5 of 23 proteins, 21.7%4.29 −070.00%SERPINC1, FETUA, KNG1, AMBP, SERPING1
Cell fraction5 of 23 proteins, 21.7%0.004052.29%EGF, IGHG2, IGHG1, CUBN, AMBPPeptidase inhibitor activity5 of 23 proteins, 21.7%4.84 −070.00%SERPINC1, FETUA, KNG1, AMBP, SERPING1
Cytoplasmic membrane-bounded vesicle5 of 23 proteins, 21.7%0.000550.15%TF, EGF, CUBN, KNG1, SERPING1Peptidase regulator activity5 of 23 proteins, 21.7%1.10 −060.00%SERPINC1, FETUA, KNG1, AMBP, SERPING1
Membrane-bounded vesicle5 of 23 proteins, 21.7%0.000620.29%TF, EGF, CUBN, KNG1, SERPING1Enzyme inhibitor activity5 of 23 proteins, 21.7%8.50 −060.00%SERPINC1, FETUA, KNG1, AMBP, SERPING1
Cytoplasmic vesicle part4 of 23 proteins, 17.4%0.000240.17%EGF, CUBN, KNG1, SERPING1Transporter activity5 of 23 proteins, 21.7%0.005272.88%CUBN, APOD, AZGP1, PTGDS, AMBP
Stored secretory granule4 of 23 proteins, 17.4%5.33 −050.22%TF, EGF, KNG1, SERPING1Carbohydrate binding3 of 23 proteins, 13.0%0.006562.50%SERPINC1, GAA, KNG1
Membrane fraction4 of 23 proteins, 17.4%0.007962.69%IGHG2, IGHG1, CUBN, AMBPLipid binding3 of 23 proteins, 13.0%0.00922.82%APOD, AZGP1, PTGDS
Insoluble fraction4 of 23 proteins, 17.4%0.008972.81%IGHG2, IGHG1, CUBN, AMBPSerine-type endopeptidase inhibitor activity3 of 23 proteins, 13.0%9.99 −050.00%SERPINC1, AMBP, SERPING1, E9KL23
Apical plasma membrane3 of 23 proteins, 13.0%0.000690.27%TF, CUBN, UMODHemoglobin binding2 of 23 proteins, 8.7%1.36 −050.00%HP, CUBN
Perinuclear region of cytoplasm3 of 23 proteins, 13.0%0.005652.58%TF, GLB1, PTGDSFatty acid binding2 of 23 proteins, 8.7%0.000760.73%AZGP1, PTGDS
Apical part of cell3 of 23 proteins, 13.0%0.001460.94%TF, CUBN, UMODCysteine-type endopeptidase inhibitor activity2 of 23 proteins, 8.7%0.000840.83%FETUA, KNG1
Lytic vacuole3 of 23 proteins, 13.0%0.00261.89%CUBN, GLB1, GAAMonocarbox-ylic acid binding2 of 23 proteins, 8.7%0.001610.92%AZGP1, PTGDS
Lysosome3 of 23 proteins, 13.0%0.00261.79%CUBN, GLB1, GAAHydrolase activity, hydrolyzing O-glycosyl compounds2 of 23 proteins, 8.7%0.003542.29%GLB1, GAA
Platelet alpha granule lumen3 of 23 proteins, 13.0%2.55 −050.00%EGF, KNG1, SERPING1Protein kinase regulator activity2 of 23 proteins, 8.7%0.004182.13%EGF, FETUA
Secretory granule lumen3 of 23 proteins, 13.0%1.37 −050.00%EGF, KNG1, SERPING1Kinase regulator activity2 of 23 proteins, 8.7%0.005412.71%EGF, FETUA
Cytoplasmic membrane-bound vesicle lumen3 of 23 proteins, 13.0%1.55 −050.00%EGF, KNG1, SERPING1Hydrolase activity, acting on glycosyl bonds2 of 23 proteins, 8.7%0.00562.78%GLB1, GAA
Vesicle lumen3 of 23 proteins, 13.0%1.74 −050.00%EGF, KNG1, SERPING1Tetrapyrrole binding2 of 23 proteins, 8.7%0.008412.67%CUBN, AMBP
Platelet alpha granule3 of 23 proteins, 13.0%2.55 −050.00%EGF, KNG1, SERPING1Heparin binding2 of 23 proteins, 8.7%0.006082.63%SERPINC1, KNG1
Vacuole3 of 23 proteins, 13.0%0.004232.27%CUBN, GLB1, GAA
Extrinsic to membrane2 of 23 proteins, 8.7%0.005322.61%CUBN, UMOD
Lysosomal membrane2 of 23 proteins, 8.7%0.006992.64%CUBN, GAA
Endocytic vesicle2 of 23 proteins, 8.7%0.003322.10%TF, CUBN
Coated pit2 of 23 proteins, 8.7%0.001130.88%TF, CUBN
Cell projection membrane2 of 23 proteins, 8.7%0.008992.71%CUBN, UMOD