Clinical Utility of Serum Autoantibodies Detected by Protein Microarray in Melanoma
Table 1
Patient and tumor characteristics of the study cohort.
Characteristic
Total
Node negative
Node positive
P value1
Frequency
79
47
32
Age
Mean (SD)
51.9 (12.6)
51.8 (13.2)
52.0 (12.0)
0.944
Gender
Males: N (%)
38 (48.1)
22 (46.8)
16 (50.0)
0.781
Females: N (%)
41 (51.9)
25 (53.2)
16 (50.0)
Breslow depth
Mean (SD)
2.39 (1.65)
1.94 (1.15)
3.11 (2.04)
0.007
Mitotic rate
Mean (SD)
5.51 (5.72)
4.45 (4.93)
7.04 (6.50)
0.075
Ulceration
Absent: N (%)
24 (30.4)
35 (74.5)
16 (50.0)
0.0592
Present: N (%)
51 (64.6)
11 (23.4)
13 (40.6)
Unknown: N (%)
4 (5.0)
1 (2.1)
3 (9.4)
ASAH1
Mean (SD)
803 (353)
837 (432)
753 (179)
0.238
±1 SD: N (%)
68 (86.1)
36 (76.6)
32 (100)
0.008
>1 SD: N (%)
8 (10.1)
8 (17.0)
0
<1 SD: N (%)
3 (3.8)
3 (6.4)
0
CTSD
Mean (SD)
8664 (4355)
9607 (5014)
7278 (2660)
0.009
±1 SD: N (%)
62 (78.5)
33 (70.2)
29 (90.6)
0.039
>1 SD: N (%)
12 (15.2)
11 (23.4)
1 (3.1)
<1 SD: N (%)
5 (6.3)
3 (6.4)
2 (6.3)
GRP75
Mean (SD)
4087 (2107)
4221 (2367)
3891 (1671)
0.471
±1 SD: N (%)
62 (78.5)
36 (76.6)
26 (81.3)
0.913
>1 SD: N (%)
13 (16.5)
8 (17.0)
5 (15.6)
<1 SD: N (%)
4 (5.1)
3 (6.4)
1 (3.1)
GRP94
Mean (SD)
6798 (3782)
6032 (1840)
7924 (5364)
0.063
±1 SD: N (%)
70 (88.6)
47 (100)
23 (71.9)
<0.001
>1 SD: N (%)
9 (11.4)
0
9 (28.1)
<1 SD: N (%)
0
0
0
LDH
Mean (SD)
7863 (4093)
8587 (4933)
6798 (2021)
0.029
±1 SD: N (%)
68 (86.1)
37 (78.7)
31 (96.9)
0.056
>1 SD: N (%)
10 (12.7)
9 (19.2)
1 (3.1)
<1 SD: N (%)
1 (1.3)
1 (2.1)
0
Combination: ASAH1, CTSD, and LDH
Overexpressed†
22 (27.9)
20 (42.5)
2 (6.2)
<0.001
Normal
57 (72.1)
27 (57.5)
30 (93.8)
1Comparing between node-negative and node-positive groups. 2Unknown group omitted for statistical test. †Overexpressed defined as >1 SD for ASAH1, CTSD, or LDH.
