Seven-Signal Proteomic Signature for Detection of Operable Pancreatic Ductal Adenocarcinoma and Their Discrimination from Autoimmune Pancreatitis
Figure 1
MALDI MS analysis of plasma specimens from human PDAC patients and healthy subjects in the training cohort. (a) Independent training-validation-confirmation datasets of 160 training cases, 129 validation cases, and 16 confirmation cases. (b) Unsupervised hierarchical clustering analysis of 80 human PDAC patients and 80 healthy subjects in the training cohort according to the protein expression patterns of 134 MS signals. Each row represents an individual proteomic signal and each column an individual sample. The dendrogram at the top shows the similarities in protein expression profiles among the samples. Substantially elevated (red) expression of the proteins was observed in individual plasma samples. HS: healthy subjects; PDAC: pancreatic ductal adenocarcinoma. Red box case: PDAC: blue box case: healthy subject.
