Protein Markers for the Differential Diagnosis of Vascular Dementia and Alzheimer’s Disease

Table 3

Candidate biomarkers and significant ICA components. Candidate biomarkers obtained from the univariate (a) and multivariate (b) analysis are listed separately. The 𝑃 values are Benjamini-Hochberg adjusted.

(a) Univariate analysis—Mann-Whitney

m/z	Array type	𝑃 value	Direction of change in AD	ID
8295	CM10	0,0017	↑	Ubiquitin −3aa from CT
101801	CM10	0,0075	↓
4352	CM10	0,0142	↑	Alpha-1-antichymotrypsin CT fragment
4745	CM10	0,0142	↑
66676	CM10	0,0142	↓	Albumin
3515	CM10	0,0181	↑	Neuroendocrine protein 7B2 CT fragment
17379	CM10	0,0181	↓	ApoA-II dimer
2840	CM10	0,0186	↑
8614	CM10	0,0274	↑	C4a des-arg
4469	CM10	0,0305	↑
2430	CM10	0,0387	↑	Integral Membrane 2B CT fragment

(b) Multivariate analysis—ICA

m/z	Array type	𝑃 value	Direction of change in AD	ID
101801	CM10	0,0067	↓
13105	CM10	0,0067	↑
147523	CM10	0,0067	↓	IgG
16207	CM10	0,0067	↓
17379	CM10	0,0067	↓	Apolipoprotein A-II dimer
28058	CM10	0,0067	↓	Apolipoprotein A-I
66676	CM10	0,0067	↓	Albumin
79578	CM10	0,0067	↓	Transferrin
8936	CM10	0,0067	↑	C3a des-arg
90294	CM10	0,0067	↓
20934	CM10	0,0072	↑	Retinol binding protein
4745	CM10	0,0072	↑
51402	CM10	0,0077	↓
3515	CM10	0,0104	↑	Neuroendocrine protein 7B2 CT fragment
5262	IM30Ni	0,01076	↓
6973	CM10	0,0159	↑
73422	CM10	0,0182	↑
2840	CM10	0,0255	↑
15124	CM10	0,0347	↓
2249	CM10	0,0467	↓
13358	CM10	0,0471	↑	Cystatin C