Table of Contents
International Journal of Proteomics
Volume 2013 (2013), Article ID 850235, 11 pages
http://dx.doi.org/10.1155/2013/850235
Review Article

Periodontal Proteomics: Wonders Never Cease!

Department of Periodontology, Faculty of Dental Sciences, SGT University, Budhera, Gurgaon, Haryana 122505, India

Received 14 October 2013; Revised 5 December 2013; Accepted 5 December 2013

Academic Editor: Setsuko Komatsu

Copyright © 2013 Harpreet Singh Grover et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Proteins are vital parts of living organisms, as they are integral components of the physiological metabolic pathways of cells. Periodontal tissues comprise multicompartmental groups of interacting cells and matrices that provide continuous support, attachment, proprioception, and physical protection for the teeth. The proteome map, that is, complete catalogue of the matrix and cellular proteins expressed in alveolar bone, cementum, periodontal ligament, and gingiva, is to be explored for more in-depth understanding of periodontium. The ongoing research to understand the signalling pathways that allow cells to divide, differentiate, and die in controlled manner has brought us to the era of proteomics. Proteomics is defined as the study of all proteins including their relative abundance, distribution, posttranslational modifications, functions, and interactions with other macromolecules, in a given cell or organism within a given environment and at a specific stage in the cell cycle. Its application to periodontal science can be used to monitor health status, disease onset, treatment response, and outcome. Proteomics can offer answers to critical, unresolved questions such as the biological basis for the heterogeneity in gingival, alveolar bone, and cemental cell populations.