Comparison of Heavy Labeled (SIL) Peptide versus SILAC Protein Internal Standards for LC-MS/MS Quantification of Hepatic Drug Transporters
Figure 1
Comparison of SILAC versus SIL internal standard methods. SILAC protein is added before trypsin digestion, while SIL peptide is added just before LC-MS analysis. Key: DTT, dithiothreitol; IAA, iodoacetamide; EB-II, extraction buffer II.
