Research Article
The Effect of Alendronate on Proteome of Hepatocellular Carcinoma Cell Lines
Table 2
Differentially expressed proteins identified with nano LC-MS/MS from Huh-7 cell lines.
| | Spot no. |
Protein Name | Accession no. | Sequence coverage% | Mol·wt·kDa | pI | Protein expression | Peptide matches | Function |
| | 1 | Heat shock protein 90 | P08238 | 6 | 90 | 4.73 | ↑ | 3 (1) | Stress responce | | 2 | 60 kDa Heat shock protein | P10809 | 34 | 61 | 5.7 | ↑ | 28 (17) | Protein folding | | 3 | Protein dicaudal D homolog 1 isoform 1 | Q96G01 | 6 | 111 | 5.6 | ↓ | 9 (3) | Interacts with RAB6A | | 4 | Signal transducer and activator of transcription 1-alpha/beta | P42224 | 4 | 87 | 5.7 | ↓ | 3 (1) | Signal transduction | | 5 | Ras-specific guanine nucleotide-releasing factor | Q86X27 | 3 | 65 | 8.86 | ↓ | 3 (2) | Signal transduction | | 6 | Annexin A5 | P08758 | 24 | 36 | 4.9 | ↑ | 8 (6) | Blood coagulation, haemostasis, signal transduction | | 7 | Triosephosphate isomerase | P60174 | 13 | 26.8 | 7.10 | ↑ | 2 (2) | Metabolism | | 8 | Interleukin-7 | P13232 | 8 | 20 | 8.87 | ↓ | 5 (1) | Growth factor activity | | 9 | Glutathione S-transferase P | P09211 | 49 | 235 | 5.4 | ↓ | 13 (11) | Antiapoptosis, detoxification | | 10 | Peroxiredoxin-2 | P32119 | 29 | 22 | 5.66 | ↑ | 5 (5) | Antiapoptosis, signal transduction |
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