Quantitative Proteomics and Lipidomics Analysis of Endoplasmic Reticulum of Macrophage Infected with Mycobacterium tuberculosis

Figure 4

Schematic representation of ER perturbations upon H37Ra infection of THP-1 cell. ATP2A2 was downregulated in H37Ra infected cells and this inhibits SERCA activity. Simultaneous increase in PC/PE ratio also blocks SERCA activity, with the consequent increase in cytosolic calcium. This, in turn, likely promotes phagolysosomal fusion and consequent elimination of the mycobacteria. However, SERCA in normal condition is responsible for the maintenance of calcium homeostasis. Blue arrow indicates the downregulation while red arrow represents the upregulation.