Table of Contents
International Journal of Proteomics
Volume 2015, Article ID 841769, 12 pages
http://dx.doi.org/10.1155/2015/841769
Research Article

SILAC-Based Quantitative Proteomic Analysis of Diffuse Large B-Cell Lymphoma Patients

1Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden
2Sahlgrenska Academy, University of Gothenburg, 413 45 Göteborg, Sweden
3Section of Hematology, Kungälv Hospital, 442 83 Kungälv, Sweden
4Section of Hematology and Coagulation, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden
5Department of Pathology and Cytology, Sahlgrenska University Hospital, 413 45 Göteborg, Sweden
6Unit of Hematology, Department of Medicine, Södra Älvsborg Hospital, 504 55 Borås, Sweden

Received 28 December 2014; Accepted 23 March 2015

Academic Editor: Richard Christopherson

Copyright © 2015 Ulla Rüetschi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental Table 1: Clinical characteristics of patients in the study. Patients 1–5 had early relapse/refractory disease; patients 6–10 are long term progression-free.

Supplemental Table 2: List of all 3588 proteins that were identified in the SILAC-based proteomic analysis using LC-MS/MS. 3,027 (84%) of the identified proteins were successfully quantified in at least one of the samples. Identification and quantification in all samples were obtained for 1305 proteins.

Supplemental Table 3: All 87 proteins that were significantly (Student’s t-test, P < 0.05) differentially expressed between the two patient groups. 66 proteins were overexpressed in the group of progression-free patients; 21 proteins were instead overexpressed in the relapsed/refractory group.

  1. Supplementary Material