SILAC-Based Quantitative Proteomic Analysis of Diffuse Large B-Cell Lymphoma Patients

Table 1

The most functionally relevant differentially expressed proteins.

Protein name	ID	Fold change; (cur/rel)	value	Function
WAFL	Q5T1M5	6.50	0.021	Regulation of actin and microtubule dynamics
STAT1	P42224	5.87	0.034	Inducer of apoptosis; negative regulation of NF-kappaB signalling
Tetraspanin CD82	P27701	5.15	0.014	Attenuation of plasma membrane-dependent actin organization
EHD4	Q9H223	4.02	0.037	Regulation of endocytic transport
Integrin beta-2; CD18	P05107	3.31	0.048	Transmembrane cell adhesion molecule
Drebrin-like protein	Q9UJU6	3.19	0.019	Actin-binding
ARP2/3 subunit 16	O15511	2.94	0.006	Regulation of actin cytoskeleton
Rac-associated protein-1	Q7L576	2.81	0.041	Regulation of actin cytoskeleton
Saposin C	P07602	2.50	0.020	Antiapoptotic effect via PI3K pathway
SHIP-1	Q92835	2.44	0.038	Involved in B cell receptor signaling pathway
CD11c; integrin alpha	P20702	2.31	0.005	Transmembrane cell adhesion molecule
ARP2/3 subunit 18	O15143	2.15	0.030	Regulation of actin cytoskeleton
Annexin A6	A6NN80	2.08	0.029	Stabilizing cortical actin cytoskeleton
Kindlin-3	Q86UX7	2.03	0.043	Activation and binding partner of integrins
Protein flightless-1 homolog	Q13045	2.01	0.007	Actin binding
CAP1	Q01518	2.00	0.025	Regulation of actin cytoskeleton
MAPK1	P28482	1.92	0.032	Involved in B-cell receptor signaling pathway
ARP2	P61160	1.90	0.035	Regulation of actin cytoskeleton
Syndapin-2	Q9UNF0	1.87	0.014	Linkage of membrane trafficking with the cytoskeleton
Moesin	P26038	1.82	0.027	Actin-binding; stabilizing microtubules at cell cortex
Proteasome MECI-1	P40306	1.77	0.041	Involved in activation of NF-kappaβ in B cells
JNK/SAPK-inhibitory kinase	Q9H2K8	1.49	0.046	Involved in B-cell receptor signaling pathway via MAPK
Caspase 3	P42574	1.42	0.047	Induction of cell apoptosis
STAG2	Q8N3U4	1.30	0.043	Tumor suppressor
eIF-2A protein kinase	P19525	0.14	0.021	Conserving protein synthesis under environmental stress
CNOT1	A5YKK6	0.34	0.032	Counteracts ER-induced stress apoptosis
NOC3	Q8WTT2	0.35	0.003	Ribosomal; essential for cell division
SKAR	Q9BY77	0.37	0.048	Promotion of cell growth via mTOR and PI3K signaling pathway
eRF3a	P15170	0.39	0.038	Inhibition of apoptosis via survivin
PDCD4	Q53EL6	0.51	0.003	Tumor suppressor via mTOR signaling pathway
MUM-1	Q15306	0.54	0.044	Transcription factor; poor prognostic marker in DLBCL
TAF15	Q92804	0.58	0.001	DNA-binding; induces rapid cell proliferation
RCC1	P18754	0.58	0.015	Chromatin regulator; involved in C-myc transcriptional activation
IKZF1	Q13422	0.61	0.044	Transcription factor; poor prognostic marker in acute lymphoblastic leukemia
SKI protein	Q13573	0.77	0.022	Protooncoprotein