Table of Contents
International Journal of Proteomics
Volume 2016 (2016), Article ID 1384523, 19 pages
Research Article

S-Nitrosylation Proteome Profile of Peripheral Blood Mononuclear Cells in Human Heart Failure

1Department of Pathology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA
2Department Preventive Medicine and Community Health, UTMB, Galveston, TX 77555, USA
3Institute for Translational Sciences, UTMB, Galveston, TX 77555, USA
4Department of Biochemistry and Molecular Biology, Sealy Center of Molecular Medicine, UTMB, Galveston TX 77555, USA
5Department of Microbiology and Immunology, UTMB, Galveston, TX 77555, USA
6Instituto de Patología Experimental, CONICET-UNSa, 4400 Salta, Argentina
7Department of Internal Medicine-Endocrinology, UTMB, Galveston, TX 77555, USA
8Institute for Human Infections and Immunity, UTMB, Galveston, TX 77555, USA

Received 30 January 2016; Revised 7 April 2016; Accepted 16 May 2016

Academic Editor: Christoph H. Borchers

Copyright © 2016 Sue-jie Koo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The proteome datasets were submitted to Ingenuity Pathway Analysis for identifying the networks and signaling pathways that were potentially disturbed in heart failure subjects. The differentially abundant proteins involved in disease and disorder network of inflammation (Figure S1), and disease and bio-function network of increased cell death and decreased cell survival (Figure S2) in heart failure (HF) subjects are presented. Further, the differentially S-NO-modified proteins involved in migration of phagocytes and inhibition of cell spreading (Figure S3) and in organismal death and cell apoptosis with production of free radicals (Figure S4) in HF subjects are presented.

  1. Supplementary Material