Research Article

Label-Free Proteomic Analysis of Flavohemoglobin Deleted Strain of Saccharomyces cerevisiae

Table 1

List of downregulated proteins in ΔYHB1 cells of S. cerevisiae.

Gene IDProtein description-fold change value

ILV5Ketol-acid reductoisomerase, mitochondrial−0.620.0002
BAT2Branched-chain-amino acid aminotransferase, cytosolic−1.050.0011
HSP26Heat shock protein 26−0.980.0015
HSP1212 kDa heat shock protein−0.750.0024
ARO2Chorismate synthase−1.110.0040
SHM2Serine hydroxymethyltransferase, cytosolic−0.890.0043
ASN1Asparagine synthetase [glutamine-hydrolyzing] 1−1.710.0045
ACO2Probable aconitate hydratase 2−0.780.0049
ARO8Aromatic amino acid aminotransferase 1−1.020.0050
ADE3C-1-Tetrahydrofolate synthase, cytoplasmic−0.540.0057
LYS20Homocitrate synthase, cytosolic isozyme−0.930.0079
ACO1Aconitate hydratase, mitochondrial−0.490.0099
HSP1010 kDa heat shock protein, mitochondrial−0.290.0104
DUG1Cys-Gly metallopeptidase YFR044C−0.220.0109
ENO1Enolase 1−0.730.0112
RPL34A60S ribosomal protein L34-A−0.700.0126
ARO4Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited−1.020.0137
HIS4Histidine biosynthesis trifunctional protein−2.820.0141
LYS1Saccharopine dehydrogenase [NAD+, L-lysine-forming]−1.330.0150
MET17Protein MET17−0.920.0164
ECM10Heat shock protein SSC3, mitochondrial−0.550.0174
LYS9Saccharopine dehydrogenase [NADP+, L-glutamate-forming]−1.170.0228
THR4Threonine synthase−0.220.0232
HSP82ATP-dependent molecular chaperone HSP82−1.020.0236
AAT2Aspartate aminotransferase, cytoplasmic−0.890.0246
BAT1Branched-chain-amino acid aminotransferase, mitochondrial−0.660.0249
DPS1Aspartyl-tRNA synthetase, cytoplasmic−0.590.0265
KGD12-Oxoglutarate dehydrogenase E1 component, mitochondrial−0.380.0305
ASN2Asparagine synthetase [glutamine-hydrolyzing] 2−0.900.0321
SSB1Heat shock protein SSB1−2.020.0327
SOD1Superoxide dismutase [Cu-Zn]−0.240.0356
THS1Threonyl-tRNA synthetase, cytoplasmic−0.070.0362
ALD6Magnesium-activated aldehyde dehydrogenase, cytosolic−0.140.0364
LEU42-Isopropylmalate synthase−1.350.0394
KRS1Lysyl-tRNA synthetase, cytoplasmic−0.720.0400
ILV3Dihydroxy-acid dehydratase, mitochondrial−0.980.0417
LEU13-Isopropylmalate dehydratase−1.020.0451
AHP1Peroxiredoxin type-2−0.370.0460
RHR2(DL)-Glycerol-3-phosphatase 1−0.440.0503
ADH3Alcohol dehydrogenase 3, mitochondrial−0.580.0546