Spectrophotometric Method for Determination of Five 1,4-Dihydropyridine Drugs Using N-Bromosuccinimide and Indigo Carmine Dye

Table 5

Application NBS/INC method for 1,4-DHP drugs’ tablets and capsules.

Product	Recovery% ± SD^a		𝐹-value^b	𝑡-value^b
	Proposed method	Official or reported method^c
Epilate capsules	98.62±0.05	99.52±0.11	0.20	1.54
Epilate retard tablets	99.21±0.04	98.51±0.13	0.10	1.63
Tenolat SR capsules*	100.33±0.85	100.52±0.66	2.00	1.11
(Pelcard SR capsules)^c	97.31±0.47	99.74±0.11	0.05	2.00
Nimotop tablets	99.46±0.20	98.61±0.19	0.25	1.82
Plendil tablets	99.24±0.07	99.24±0.13	0.82	0.41
Plentopine tablets	98.39±0.13	99.22±0.11	0.72	1.86
Logimax tablets*	99.22±0.15	99.34±0.17	0.10	0.24
(Alkapress tablets)^c	99.34±0.10	99.21±0.12	0.17	0.17
(Myodura tablets)^c	99.26±0.05	98.31±0.11	0.21	1.45
(Amlodipine tablets)^c	98.38±0.04	97.20±0.12	0.11	1.85
(Regcor tablets)^c	98.43±0.11	99.24±0.16	0.47	0.47
(Vasonorm tablets)^c	97.72±0.11	98.41±0.19	2.44	0.54

aMean of five determinations.
^bTheoretical values for 𝐹 and 𝑡 at 95% confidence limit (𝑛=5) were 6.39 and 2.78, respectively.
^cReported methods [37, 38].
*Tablets and capsules that contain two drugs.