Table of Contents
International Journal of Spectroscopy
Volume 2013, Article ID 245376, 6 pages
Research Article

Intermolecular Interactions between Eosin Y and Caffeine Using 1H-NMR Spectroscopy

Department of Chemistry, Doane College, 1014 Boswell Avenue, Crete, NE 68333, USA

Received 28 June 2013; Revised 13 September 2013; Accepted 19 September 2013

Academic Editor: Shigehiko Takegami

Copyright © 2013 Macduff O. Okuom et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


DETECHIP has been used in testing analytes including caffeine, cocaine, and tetrahydrocannabinol (THC) from marijuana, as well as date rape and club drugs such as flunitrazepam, gamma-hydroxybutyric acid (GHB), and methamphetamine. This study investigates the intermolecular interaction between DETECHIP sensor eosin Y (DC1) and the analyte (caffeine) that is responsible for the fluorescence and color changes observed in the actual array. Using 1H-NMR, 1H-COSY, and 1H-DOSY NMR methods, a proton exchange from C-8 of caffeine to eosin Y is proposed.