Development and Validation of First-Order Derivative Spectrophotometry for Simultaneous Determination of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Dosage Form

Table 1

Summary of validation parameters.

Parameters	LCT	PHE
% Recovery	99.14%–100.43%	98.73%–100.83%
Precision (% RSD)
Repeatability (𝑛=6)	1.06	0.96
Intraday (𝑛=3)	0.53–0.66	0.79–1.11
Interday (𝑛=3)	0.87–1.10	1.01–1.60
Limit of detection (μg/mL)	0.19	0.64
Limit of quantification (μg/mL)	0.57	1.94
Solution stability	Stable for 24 hrs.	Stable for 24 hrs.