International Journal of Spectroscopy / 2014 / Article / Tab 4 / Research Article
New Kinetic Spectrophotometric Method for Determination of Fexofenadine Hydrochloride in Pharmaceutical Formulations Table 4 Determination of FEX in different pharmaceutical formulations by the proposed and official methods.
Formulation Label claim % Founda ± SD Proposed methods
Official method [31 ] Initial rate Fixed time
Allergy stopb 60 mg/Cap 100.75 ± 0.19 101.04 ± 0.21 100.79 ± 0.13 t = 1.99t = 2.17t = 1.32F = 2.14F = 2.61 120 mg/Tab 101.06 ± 0.20 100.12 ± 0.18 101.05 ± 0.15 t = 2.05t = 1.75t = 1.28F = 1.78F = 1.44 180 mg/Tab 99.98 ± 0.18 100.60 ± 0.20 99.78 ± 0.14 t = 1.68 t = 1.36t = 1.79F = 1.65F = 2.04 Fexofenadinec 60 mg/Cap 100.27 ± 0.15 101.00 ± 0.13 100.84 ± 0.11 t = 1.99t = 1.00t = 1.88F = 1.86F = 1.41 Fenadind 120 mg/Tab 101.96 ± 0.13 100.26 ± 0.14 99.69 ± 0.12 t = 1.67t = 2.06t = 1.24F = 1.17F = 1.52 180 mg/Tab 100.95 ± 0.20 101.08 ± 0.23 100.52 ± 0.18 t = 1.70 t = 1.12 t = 1.81F = 1.23F = 1.63
Five independent analyses. At 95% confidence level t -value is 2.776 and F -value is 6.26.
b Supplied by Pharmasyr, Syria; c supplied by Ibn-Alhaytham, Syria; d supplied by BPI, Syria.