Development and Validation of a Discriminating In Vitro Dissolution Method for Oral Formulations Containing Satranidazole

Table 9

Change in agitation rate.

Time (minutes)	At 73 rpm	At 75 rpm	At 77 rpm
Average % release ± SD (𝑛=6)
0	0	0	0
5	8.98 ± 0.3987	8.17 ± 0.5679	8.21 ± 0.5012
10	35.18 ± 0.5671	36.93 ± 0.5712	33.94 ± 0.6782
15	44.45 ± 0.6745	42.81 ± 0.7986	45.24 ± 0.5867
30	66.23 ± 0.7681	69.81 ± 0.6897	66.87 ± 0.6139
45	76.56 ± 0.8142	74.26 ± 0.5893	78.43 ± 0.7831
60	87.32 ± 0.4587	88.23 ± 0.6897	88.42 ± 0.4879
Average at 60 min	87.99 ± 0.7633
% RSD at 60 min	0.668