Research Article
The Use of a Green Fluorescent Protein Porcine Model to Evaluate Host Tissue Integration into Extracellular Matrix Derived Bionanocomposite Scaffolds
Table 1
Qualitative and semiquantitative scoring criteria. Quantitative score is per 400x field.
| Criteria | 0 | 1 | 2 | 3 |
| Cellular infiltration | 0–50 cells | 51 and 100 cells | 101–150 cells | >150 cells | Multinucleated giant cells (MNGC) | 0 MNGC | 1-2 MNGC | 3-4 MNGC | >5 MNGC | Vascularity | Either 0 or 1 blood vessel | 2–5 blood vessels | 6–10 blood vessels | >10 blood vessels | Connective tissue organization | Original scaffold is intact | Original scaffold disrupted; poorly organized new host ECM present | Mixture of highly organized and poorly organized connective tissue | Highly organized connective tissue present | Fibrous encapsulation | No fibrous encapsulation | Less than 50% of the periphery has fibrous encapsulation | 50%–90% of the periphery has fibrous encapsulation | Complete fibrous encapsulation | Scaffold degradation | Scaffold is intact | Scaffold fibers are disrupted and present in groups or large bundles | Scaffold fibers are disrupted and present in single fibers or small bundles | No scaffold fibers remain |
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