Table of Contents
ISRN Dentistry
Volume 2011, Article ID 125168, 7 pages
Research Article

Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

1Department of Pharmacology, University of Greifswald, 17475 Greifswald, Germany
2Department of Dental Clinics, Unit of Periodontology, University of Greifswald, 17475 Greifswald, Germany
3Department of Community Medicine, University of Greifswald, 17475 Greifswald, Germany
4Department of Clinical Chemistry, University of Greifswald, 17475 Greifswald, Germany

Received 8 August 2011; Accepted 4 September 2011

Academic Editors: Y. Abe and F. Cairo

Copyright Β© 2011 Peter Meisel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Common risk factors of periodontitis and cardiovascular diseases fuel the debate on interrelationships between them. The aim is to prove whether statins may influence periodontal parameters by affecting either of these factors. Out of the 4,290 subjects of SHIP (Study of Health in Pomerania), we included subjects aged >30 years (219 with statins, 2937 without) and excluded edentulous. We determined periodontal measures, cholesterol fractions, and inflammation markers. Statin use and periodontal risk factors were assessed. Gingival plaque and periodontal attachment loss were associated with systemic LDL cholesterol ( 𝑃 < 0 . 0 0 1 ) and C-reactive protein CRP ( 𝑃 = 0 . 0 1 9 ) revealing interaction with statin use. When adjusted for age, sex, smoking, diabetes, education, and dental service, statins were identified as effect modifiers abolishing the relationship between attachment loss and LDL and between gingival plaque and LDL (interactions 𝑃 < 0 . 0 0 1 ). No statin-related interaction was detected with increase in CRP. The interaction supports the view of inter-relationships between periodontal and systemic inflammatory mediators.