Cholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers

Table 3

Logistic regression: mean clinical attachment loss (CAL) and the risk of belonging to the LDL concentration range 100–160 mg/dL or >160 mg/dL with reference LDL < 100 mg/dL.

Dependent variable	LDL 100–<160 mg/dL		LDL≥160 mg/Dl
	OR (95% CI)	𝑃	OR (95% CI)	𝑃
CAL, mm, crude	1.17 (1.10–1.25)	<0.001	1.30 (1.21–1.39)	<0.001
Model 1 *
CAL mean, mm	1.08 (1.00–1.16)	0.064	1.11 (1.02–1.21)	0.013
Model 2 *
CAL mean, mm	1.11 (1.02–1.20)	0.020	1.21 (1.10–1.33)	<0.001
Statins	0.36 (0.24–0.53)	<0.001	0.14 (0.08–0.22)	<0.001
CAL × statin use	0.98 (0.97–1.00)	0.046	0.96 (0.94–0.98)	<0.001

*Model 1: adjusted for age (continuous), sex (male 0, female 1), HbA_1c (continuous), education (10th grade or higher), smoking (pack years), alcohol consumption (g/weekend), and last dental visit (within the last year 0, longer than one year 1).
*Model 2: as model 1 with the additional variables shown.