Table of Contents
ISRN Anesthesiology
Volume 2011 (2011), Article ID 143189, 3 pages
http://dx.doi.org/10.5402/2011/143189
Clinical Study

No Perioperative Pulmonary Complications after Restricted Oxygen Exposition in Bleomycin-Treated Patients: A Short Report

1University Department of Anaesthesiology and Pain Therapy, University Hospital Bern, Inselspital, 3010 Berne, Switzerland
2Department of Urology, University Hospital Bern, 3010 Berne, Switzerland

Received 13 September 2011; Accepted 16 October 2011

Academic Editors: E. Freye and S. J. Verbrugge

Copyright © 2011 Patrick Y. Wuethrich and Fiona C. Burkhard. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hyperoxic exposure during general anaesthesia after receiving bleomycin treatment is purported to potentiate bleomycin-induced pulmonary toxicity. The aim of this study was to retrospectively assess perioperative pulmonary complications after general anaesthesia for retroperitoneal lymphadenectomy in patients who underwent bleomycin treatment <6 months earlier. A consecutive series of 47 patients who underwent surgery after bleomycin treatment were reviewed. Anaesthesia was induced with an inspired fraction of oxygen (FiO2) of 100% for 3 minutes and pertained with a FiO2 just under 30% throughout the procedure. We assessed all potential risk factors for bleomycin-induced pulmonary toxicity. Clinical signs for pulmonary damage were documented preoperatively (dyspnea, tachypnea, nonproductive cough, and postoperative oxygen saturation problems). No pathognomic clinical signs for pulmonary damage were detected up to 7 days postoperatively. Administration of 100% oxygen for 3 minutes during induction of anaesthesia and maintaining a FiO2 < 30% during surgery was safe.