Resistance of Platelets in Hypercholesterolemia to Inhibition by Activated Coagulation Factor X

Table 3

Inhibition of ADP-induced platelet aggregation by factor Xa in normal volunteers and hypercholesterolemic patients.

Platelet-rich plasma	Addition	Platelet aggregation %
Normal controls (𝑛=12)	ADP + Tyrode’s buffer	62±13	𝑃<0.05
	ADP + factor Xa	21±20^∗
Hypercholesterolemic subject (𝑛=19)	ADP + Tyrode’s buffer	83±8	𝑃=NS
	ADP + factor Xa	74±15

*reversible aggregation only.
NS: nonsignificant.