Table of Contents
ISRN Oncology
Volume 2011 (2011), Article ID 180518, 5 pages
http://dx.doi.org/10.5402/2011/180518
Research Article

Androgen Receptor in Laryngeal Carcinoma: Could There Be an Androgen-Refractory Tumor?

1Department of Anatomy, School of Medicine, University of Patras, Terpsitheas 61, 26442 Patras, Greece
2Otorhinolaryngology-Head and Neck Surgery Department, School of Medicine, University of Patras, Terpsitheas 61, 26442 Patras, Greece

Received 1 October 2011; Accepted 23 October 2011

Academic Editor: E. Sueoka

Copyright © 2011 Anastasios K. Goulioumis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Androgen receptors (ARs) which are implicated in the pathogenesis of several malignancies can also be a possible downstream effector in laryngeal cancer. In the present study, 97 invasive squamous laryngeal carcinomas were studied by immunohistochemistry for protein expression of AR. Androgen receptors were expressed in 52.6% of tumor specimens, suggesting their implication in the pathogenesis of this tumor. Our study's aim was to investigate the hypothetical scenario of an androgen refractory laryngeal carcinoma where androgen receptors can be activated by nodal molecules in the course of an Epithelial-to-mesenchymal transition (EMT) phenomenon. In line with this we correlated AR expression with the expression of ILK, p-Akt, E-cadherin, β-catenin in our sample as well as with tumor grade and TNM stage. A reverse correlation between nuclear AR and cytoplasmic ILK expression was evidenced, indicating an interaction of those molecules in laryngeal carcinoma. Finally in our material, in those carcinomas that were expressing ARs, stronger nuclear expression of the receptor was characterized by poorer cell differentiation and correlated with the acquisition of EMT features like E-cadherin loss and β-catenin translocation raising a question whether activated ARs can drive an EMT procedure.