Table of Contents
ISRN Pediatrics
Volume 2011, Article ID 182964, 4 pages
http://dx.doi.org/10.5402/2011/182964
Research Article

Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital

1Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5
2Clinical Research Unit, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada K1H 8L1
3Division of Pediatric Gastroenterology, Hepatology & Nutrition, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, Canada K1H 8L1

Received 24 November 2010; Accepted 13 December 2010

Academic Editors: E. Salazar-Lindo and R. S. Trompeter

Copyright © 2011 Paulina Cybulska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. Clinical presentation of viral hepatitis ranges from mild symptoms to fulminant hepatitis. Our aim is to describe clinical presentation and outcomes of children with viral hepatitis from the Eastern Ontario/Western Quebec regions of Canada. Methods. Retrospective chart review of children diagnosed with viral hepatitis at our institution from January 1, 1998, to December 31, 2007. Results. There were 261 charts reviewed, only 64 had a confirmed viral etiology: 34 (53%) hepatitis B (HBV), 16 (25%) hepatitis C (HCV), 4 (6.3%) hepatitis A (HAV), 7 (11%) cytomegalovirus (CMV), and 3 (4.7%) Epstein-Barr virus (EBV). Children with HBV presented at a mean age of 6 . 4 ± 4 . 6  years. Spontaneous seroconversion (appearance of HBVeAb and loss of HBVeAg) occurred in 21/34 (61.7%). Children with acute hepatitis (HAV, CMV, and EBV) presented with mild abdominal pain, jaundice, and fevers. Overall outcome was excellent. Conclusion. Acute and chronic hepatitis in children has a benign course; moreover, HBV spontaneous seroconversion is common in pediatric patients.