Synthesis, Physiochemical Properties, Photochemical Probe, and Antimicrobial Effects of Novel Norfloxacin Analogues

Table 4

Various physicochemical properties of highly bioactive compounds.

Compd. No.	MIC at 30 μg/disc				Mol. Mass	Melting point		Solubility^c in water (20^∘C), μg/L
	B.S	S.A	E.C	K.P		CHCl3^a	Cyclo-Hexane^b
20	6	10	10	8	299	90	87	200
21	6	10	10	9	327	191	186	300
11	6	10	6	10	374	74	70	90
23	6	10	6	9	366	111	107	350
12	15	10	12	12	442	285	—	400
Ny	6	6	6	6	—	—	—	—
Na	32	30	30	32	—	—	—	—

^aCrystals cyclisation from CHCl₃; ^bCrystals cyclisation from cyclohexane; ^chydrolysis characteristics at pH 5.7 and 9 and at 24^∘C. The tested compounds have a very low rate of hydrolysis, which is considered stable in suspension concentrations under normal condition.