Table of Contents
ISRN Organic Chemistry
Volume 2011 (2011), Article ID 195850, 5 pages
http://dx.doi.org/10.5402/2011/195850
Research Article

Ferric Hydrogensulfate [ F e ( H S O 𝟒 ) 𝟑 ] As a Reusable Heterogeneous Catalyst for the Synthesis of 5-Substituted-1H-Tetrazoles and Amides

Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, P.O. Box 91775-1436, Mashhad, Iran

Received 11 January 2011; Accepted 7 February 2011

Academic Editors: L. Minuti, T. Ogiku, and J. Perez-Castells

Copyright © 2011 Hossein Eshghi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ferric hydrogensulfate catalyzed the synthesis of 5-substituted 1H-tetrazoles via [2 + 3] cycloaddition of nitriles and sodium azide. This method has the advantages of high yields, simple methodology, and easy workup. The catalyst can be recovered by simple filtration and reused delivering good yields. Also, ferric hydrogensulfate catalyzed the hydrolysis of nitriles to primary amides under aqueous conditions. Various aliphatic and aromatic nitriles converted to the corresponding amides in good yields without any contamination with carboxylic acids.