Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks

Figure 2

Acute effects of SO on ACN spontaneous activity and morphology. (a) A stepwise dose-dependent inhibition of mean spike rate per min (15 units). The activity was partially reversible with a single wash. (b) Neurons and glia in reference medium (b1) and after 20 min in 3.0 mM SO (b2). No overt changes in morphology can be identified. The round black circles seen in the figures are gold-plated electrodes.