Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks
Figure 6
Spontaneous recovery from SO application (1.0 and 2.0 mM) and influence of 40 μM bicuculline. (a) The network shows a 35% recovery at 60 min after 1.0 mM SO application. Note the rapid loss of activity (1-2 min) implying interactions with membrane surface receptors. A 2.0 mM application of SO reduced activity by more than 90%, with no recovery. (b) In the presence of bicuculline, the network shows almost complete recovery to the bicuculline reference with 1.0 mM SO. A 2.0 mM SO application stops all activity followed by a spontaneous recovery to more than 50% of reference. R = Reference; B = Bicuculline.
