Surgical Brain Metastases: Management and Outcome Related to Prognostic Indexes: A Critical Review of a Ten-Year Series

Table 1

Summary of three main different prognostic indexes, recursive partitioning analisys (RPA), score index for radiosurgery in brain metastases (SIR), graded prognostic assessment (GPA).

(a) Recursive partitioning analysis (RPA)

	Class I	Class II	Class III
Age (years)	<65	All patients not in Class I or III	<70
KPS	≥70
Control of primary tumor	Yes
Extracranial metastases	No

(b) Score index for radiosurgery in brain metastases (SIR)

	Score 0	Score 1	Score 2
Age (years)	≥60	51–59	<= 50
KPS	≤50	60–70	>70
Systemic disease status	Progressive disease	Progressive-stable disease	Complete clinical remission—no evidence of disease
Largest lesion volume (cm^3)	>13	5–13	<5
Number of lesions	≥3	2	1

(c) Graded prognostic assessment (GPA)

	Score 0	Score 0.5	Score 1
Age (years)	>60	50–59	<50
KPS	<70	70–80	90–100
Number of CNS metastases	>3	2-3	1
Extracranial metastases	Present	—	None