Table of Contents
ISRN Endocrinology
Volume 2011 (2011), Article ID 219494, 4 pages
http://dx.doi.org/10.5402/2011/219494
Case Report

Results of the Prolonged Use of Subcutaneous Continuous Infusion of Hydrocortisone in a Man with Congenital Adrenal Hyperplasia

Service d'Endocrinologie, Hôpital de la Cavale Blanche CHU de Brest, Boulevard Tanguy Prigent, 29609 Brest Cedex, France

Received 24 December 2010; Accepted 16 February 2011

Academic Editors: M. De Rosa, J. A. Rillema, and J. W. Tomlinson

Copyright © 2011 Emmanuel Sonnet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This is a case report study of a young man with Congenital Adrenal Hyperplasia (CAH) who has been treated during 2 years by a subcutaneous continuous infusion hydrocortisone (SCIH) to optimize his treatment. Hydrocortisone was delivered via an insulin infusion device. We also studied the evolution of testicular adrenal rest tumors (TARTs) and the quality of life through SF36 survey. Four rates were determined, with a total of 47 mg per day. Biochemical parameters were normalized at 2 months. The SF36 questionnaire showed a progress of well-being. The weight decreased to 106 kg, that is, −5 kg (height: 1.71 m). Unfortunatly, there was no change of the TARTs. Two episodes of dermohypodermitis, with abscess at the infusion site, were observed. This case demonstrates the feasibility of prolonged SCIH therapy in patients with CAH, reporting positive effects on quality of life and on BMI.