Evaluation of the In Situ Hybridization Signal Patterns of Liquid-Based Cytological Human Papillomavirus Specimens for Diagnosing Squamous Intraepithelial Lesion
The scatter plot graph of c-ISH positive cells of LSIL or HSIL patients in Table 2. c-ISH positive cells of LSIL or HSIL patients were plotted by signal patterns (E or I) for (a) total cell population (L (large-sized cell) + M (medium-sized cell) + S (small-sized cell)) or (b) L cell (large-sized cell) population. Follow-up conditions of patients: *1 (case 4), NILM (PCR 58+, ISH+); *2 (case 15), CIN2, ISH-; *5 (case 13), HSIL (moderate dysplasia) (PCR 16+, ISH+); *6 (case 5), *7 (case 6), *8 (case 12), *11 (case 14), *12 (case 8): NILM (PCR-, ISH-); *9 (case 11), CIN1, conization; *10 (case 9), CIN3 (CIS), conization; *13 (case 7); NILM. h-ISH of *3 and *4 patient: *3 (case 25), The number of E (+) S-cells were more than that of I (+) L + M +S-cell.; *4 (case 26), Both CIN1 and CIN3 lesion were observed in the same histological specimen.