Table of Contents
ISRN Pharmaceutics
Volume 2011, Article ID 237501, 8 pages
http://dx.doi.org/10.5402/2011/237501
Research Article

Preparation of Fluconazole 𝜷 -Cyclodextrin Complex Ocuserts: In Vitro and In Vivo Evaluation

1Department of Pharmaceutics, College of Pharmacy, Sri Krishnadevaraya University, Andhra Pradesh, Anantapur 515003, India
2Analytical Lab, Department of Chemistry, Sri Krishnadevaraya University, Andhra Pradesh, Anantapur 515003, India

Received 13 April 2011; Accepted 12 June 2011

Academic Editors: J. V. de Julián-Ortiz, Y. Murata, and G. Yener

Copyright © 2011 Hindustan Abdul Ahad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The main purpose of the present study was to develop ocuserts of Fluconazole 𝛽 -CD (beta-cyclodextrin) complex and to evaluate both in vitro and in vivo. Fluconazole was made complex with 𝛽 -CD, and the release rate was controlled by HPMC K4M and ethyl cellulose polymers using dibutyl Phthalate as permeability enhancer. Drug-polymer interactions were studied by Fourier transform infrared spectroscopic studies. The formulated ocuserts were tested for physicochemical parameters of in vitro release and in vivo permeation in rabbits. The optimized formulations (F-5 and F-8) were subjected to stability studies. The formulated ocuserts were found to have good physical characters, thickness, diameter, uniformity in weight, folding endurance, less moisture absorption, and controlled release of drug both in vitro and in vivo. The optimized formulations retained their characteristics even after stability studies. The study clearly showed that this technique was an effective way of formulating ocuserts for retaining the drug concentration at the intended site of action for a sufficient period of time and to elicit the desired pharmacological response.