Table of Contents
ISRN Pharmaceutics
Volume 2011, Article ID 237501, 8 pages
http://dx.doi.org/10.5402/2011/237501
Research Article

Preparation of Fluconazole 𝜷 -Cyclodextrin Complex Ocuserts: In Vitro and In Vivo Evaluation

1Department of Pharmaceutics, College of Pharmacy, Sri Krishnadevaraya University, Andhra Pradesh, Anantapur 515003, India
2Analytical Lab, Department of Chemistry, Sri Krishnadevaraya University, Andhra Pradesh, Anantapur 515003, India

Received 13 April 2011; Accepted 12 June 2011

Academic Editors: J. V. de Julián-Ortiz, Y. Murata, and G. Yener

Copyright © 2011 Hindustan Abdul Ahad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. H. L. Lee and I. R. Robinson, “Ocuserts for improved drug delivery and better patient compliance,” Journal of Pharmaceutical Sciences, vol. 68, no. 1, p. 673, 1979. View at Google Scholar
  2. N. Udupa, “In vitro evaluation of flurbiprofen ophthalmic inserts,” Pharma Times, vol. 31, no. 361, p. 26, 1993. View at Google Scholar
  3. S. K. Rastogi, N. Vayas, and B. Mishra, “In vitro and in vivo evaluation of pilocarpine hydrochloride ocuserts,” The Eastern Pharmacist, vol. 99, no. 458, p. 41, 1996. View at Google Scholar
  4. F. Gurtler and R. Gurny, “Patent literature review of ophthalmic inserts,” Drug Development and Industrial Pharmacy, vol. 21, no. 1, pp. 1–18, 1995. View at Google Scholar · View at Scopus
  5. M. F. Saettone and L. Salminen, “Ocular inserts for topical delivery,” Advanced Drug Delivery Reviews, vol. 16, no. 1, pp. 95–106, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Gurtler, V. Kaltsatos, B. Boisramé, and R. Gurny, “Long-acting soluble bioadhesive ophthalmic drug insert (BODI) containing gentamicin for veterinary use: optimization and clinical investigation,” Journal of Controlled Release, vol. 33, no. 2, pp. 231–236, 1995. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. C. Lee, J. W. Millard, G. J. Negvesky, S. I. Butrus, and S. H. Yalkowsky, “Formulation and in vivo evaluation of ocular insert containing phenylephrine and tropicamide,” International Journal of Pharmaceutics, vol. 182, no. 1, pp. 121–126, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Ramkanth, C. M. Chetty, M. Alagusundaram, S. Angalaparameswari, V. S. Thiruvengadarajan, and K. Gnanaprakash, “Design and evaluation of diclofenac sodium ocusert,” International Journal of PharmTech Research, vol. 1, no. 4, pp. 1219–1223, 2009. View at Google Scholar · View at Scopus
  9. J. Ceulemans, A. Vermeire, E. Adriaens, J. P. Remon, and A. Ludwig, “Evaluation of a mucoadhesive tablet for ocular use,” Journal of Controlled Release, vol. 77, no. 3, pp. 333–344, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. D. C. Bibby, N. M. Davies, and I. G. Tucker, “Mechanisms by which cyclodextrins modify drug release from polymeric drug delivery systems,” International Journal of Pharmaceutics, vol. 197, no. 1-2, pp. 1–11, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. J. K. Pandit, S. L. Harikumar, D. N. Mishra, and J. Balasubramaniam, “Effect of physical cross-linking on in vitro and ex vivo permeation of indomethacin from polyvinyl alcohol ocular inserts,” Indian Journal of Pharmaceutical Sciences, vol. 65, no. 2, pp. 146–151, 2003. View at Google Scholar · View at Scopus
  12. M. M. A. Abdel-Mottaleb, N. D. Mortada, A. A. Elshamy, and G. A. S. Awad, “Preparation and evaluation of fluconazole gels,” Egyptian Journal of Biomedical Science, vol. 23, pp. 266–286, 2007. View at Google Scholar
  13. G. L. Amidon, H. Lennernas, V. P. Shah, and J. R. Crison, “A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability,” Pharmaceutical Research, vol. 12, no. 3, pp. 413–420, 1995. View at Google Scholar · View at Scopus
  14. D. N. Mishra and R. M. Gilhotrar, “Design and characterization of bio-adhesive in-situ gelling ocular inserts of gatifloxacin sesquihydrate,” Daru, vol. 16, no. 1, pp. 1–8, 2008. View at Google Scholar · View at Scopus
  15. G. V. M. M. Babu, K. H. Sankar, C. P. S. Narayan, and K. V. R. Murthy, “Design and evaluation of gentamicin ophthalmic inserts,” Indian Journal of Pharmaceutical Sciences, vol. 63, no. 5, p. 408, 2001. View at Google Scholar
  16. A. Y. Soad, N. E. Omaima, and B. B. Emad, “Design and in vitro/in vivo evaluation of novel mucoadhesive buccal discs of an antifungal drug: relationship between swelling, erosion, and drug release,” AAPS PharmSciTech, vol. 9, no. 4, pp. 1207–1217, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. A. S. Alam and E. L. Parrott, “Effect of adjuvants on tackiness of polyvinylpyrrolidone film coating,” Journal of Pharmaceutical Sciences, vol. 61, no. 2, pp. 265–269, 1972. View at Google Scholar · View at Scopus
  18. S. Kawakami, K. Nishida, T. Mukai et al., “Controlled release and ocular absorption of tilisolol utilizing ophthalmic insert-incorporated lipophilic prodrugs,” Journal of Controlled Release, vol. 76, no. 3, pp. 255–263, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. D. Meisner and M. Mezei, “Liposome ocular delivery systems,” Advanced Drug Delivery Reviews, vol. 16, no. 1, pp. 75–93, 1995. View at Publisher · View at Google Scholar · View at Scopus
  20. M. S. Nagarsenker, V. Y. Londhe, and G. D. Nadkarni, “Preparation and evaluation of liposomal formulations of tropicamide for ocular delivery,” International Journal of Pharmaceutics, vol. 190, no. 1, pp. 63–71, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Parodi, E. Russo, G. Caviglioli, S. Cafaggi, and G. Bignardi, “Development and characterization of a buccoadhesive dosage form of oxycodone hydrochloride,” Drug Development and Industrial Pharmacy, vol. 22, no. 5, pp. 445–450, 1996. View at Google Scholar · View at Scopus
  22. S. Y. Amin, “Development and characterization of a controlled release buccoadhesive dosage form of benzydamine hydrochloride,” Egyptian Journal of Biomedical Science, vol. 6, pp. 134–149, 2000. View at Google Scholar
  23. G. Levy, “Effect of certain tablet formulation factors on dissolution rate of the active ingredients,” Journal of Pharmaceutical Sciences, vol. 52, pp. 1039–1051, 1963. View at Google Scholar
  24. M. S. El-Samaligy, S. A. Yahia, and E. B. Basalious, “Formulation and evaluation of diclofenac sodium buccoadhesive discs,” International Journal of Pharmaceutics, vol. 286, no. 1-2, pp. 27–39, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. A. Ali, “Preparation and evaluation of reservoir type ocular inserts of sodium chromoglycate,” Indian Drugs, vol. 29, no. 4, p. 157, 1991. View at Google Scholar
  26. N. Kannan, “Laboratory manual in general microbiology,” in Laboratory Manual In General Microbiology, p. 112, Palani Paramount Publication, Palani, India, 1996. View at Google Scholar
  27. I. P. Kaur, M. Singh, and M. Kanwar, “Formulation and evaluation of ophthalmic preparations of acetazolamide,” International Journal of Pharmaceutics, vol. 199, no. 2, pp. 119–127, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Narasimhamurthy, “Formulation and evaluation of polymeric ophthalmic inserts containing diclofenac sodium,” Indian Drugs, vol. 34, no. 6, p. 336, 1997. View at Google Scholar